Rabbit Secondary Antibodies
ABclonal Technology 450 Rabbit anti-Human CD89
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils monocytes macrophages and eosinophils where it mediates immunologic responses to pathogens It interacts with IgA-opsonized targets and triggers several immunologic defense processes including phagocytosis antibody-dependent cell-mediated cytotoxicity and stimulation of the release of inflammatory mediators Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene
ABclonal Technology 488 Rabbit anti-Human MMP9
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development reproduction and tissue remodeling as well as in disease processes such as arthritis and metastasis Most MMP s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases The enzyme encoded by this gene degrades type IV and V collagens Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow and murine studies suggest a role in tumor-associated tissue remodeling
ABclonal Technology PE Rabbit anti-Human CD40 mAb
This gene is part of the TNF-receptor superfamily encoding a receptor on antigen-presenting cells that mediates immune and inflammatory responses including T cell-dependent immunoglobulin class switching memory B cell development and germinal center formation It is regulated by the AT-hook transcription factor AKNA which controls both the receptor and its ligand aiding in homotypic cell interactions The receptor interacts with TNFR2 to mediate signal transduction and is essential for amyloid-beta-induced microglial activation an early event in Alzheimer s disease Mutations in this gene cause autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3) Multiple splice variants encoding different isoforms have been identified
ABclonal Technology 488 Rabbit anti-Human IL-1B
The protein encoded by this gene is a member of the interleukin 1 cytokine family This cytokine is produced by activated macrophages as a proprotein which is proteolytically processed to its active form by caspase 1 (CASP1 ICE) This cytokine is an important mediator of the inflammatory response and is involved in a variety of cellular activities including cell proliferation differentiation and apoptosis The induction of cyclooxygenase-2 (PTGS2 COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2
Abcam Rabbit Anti-Human IgM mu chain Alexa Fluor 647
Rabbit Anti-Human IgM mu chain Alexa Fluor 647
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology 647 Rabbit anti-Human ERG
This gene encodes a member of the ETS family of transcription factors which regulate embryonic development cell proliferation differentiation angiogenesis inflammation and apoptosis The protein contains an ETS DNA-binding domain and a PNT domain involved in self-association of oncoproteins It is primarily expressed in the nucleus and plays a role in platelet adhesion to the subendothelium vascular remodeling hematopoiesis and megakaryocyte differentiation This gene is involved in chromosomal translocations leading to fusion proteins like TMPSSR2-ERG in prostate cancer EWS-ERG in Ewing s sarcoma and FUS-ERG in acute myeloid leukemia Over two dozen transcript variants have been reported though the full-length forms of many are undetermined
ABclonal Technology 488 Rabbit anti-Human IL-5
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils The encoded cytokine plays a major role in the regulation of eosinophil formation maturation recruitment and survival The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases This cytokine functions by binding to its receptor which is a heterodimer whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2 GM-CSF) This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4) interleukin 13 (IL13) and CSF2 This gene IL4 and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31
ABclonal Technology 488 Rabbit anti-Human PLZF
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus This protein is located in the nucleus is involved in cell cycle progression and interacts with a histone deacetylase Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL) Alternate transcriptional splice variants have been characterized
ABclonal Technology 450 Rabbit anti-Human LAMP2
The protein encoded by this gene is a member of a family of membrane glycoproteins This glycoprotein provides selectins with carbohydrate ligands It may play a role in tumor cell metastasis It may also function in the protection maintenance and adhesion of the lysosome Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins
Medchemexpress LLC Rabbit Anti-Human Ig 50uL | 50uL
Rabbit Anti-Human IgG H L (HRP) is a horseradish peroxidase (HRP) labeled and Rabbit-derived polyclonal antibody which served as the secondary antibody
ABclonal Technology 647 Rabbit anti-Human CD116
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2 a cytokine which controls the production differentiation and function of granulocytes and macrophages The encoded protein is a member of the cytokine family of receptors This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes Multiple transcript variants encoding different isoforms have been found for this gene with some of the isoforms being membrane-bound and others being soluble
ABclonal Technology 488 Rabbit anti-Human CD71
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis This receptor is required for erythropoiesis and neurologic development Multiple alternatively spliced variants have been identified
ABclonal Technology 488 Rabbit anti-Human CD71
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis This receptor is required for erythropoiesis and neurologic development Multiple alternatively spliced variants have been identified
ABclonal Technology PE Rabbit anti-Human CD4 mAb
This gene encodes the CD4 membrane glycoprotein of T lymphocytes The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit This gene is expressed not only in T lymphocytes but also in B cells macrophages granulocytes as well as in various regions of the brain The protein functions to initiate or augment the early phase of T-cell activation and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene
ABclonal Technology 594 Rabbit anti-Human DLL4
This gene is a homolog of the Drosophila delta gene The delta gene family encodes Notch ligands that are characterized by a DSL domain EGF repeats and a transmembrane domain